Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

Differential chloride homeostasis in the spinal dorsal horn locally shapes synaptic metaplasticity and modality-specific sensitization

Inhibition in spinal nociceptive pathways is weaker and more labile in lamina I —where thermal input is primarily processed— than in lamina II that encodes predominantly high threshold mechanical input. This explains why noxious thermal input makes spinal circuits prone to catastrophic sensitization...

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Bibliographic Details
Main Authors: Francesco Ferrini, Jimena Perez-Sanchez, Samuel Ferland, Louis-Etienne Lorenzo, Antoine G. Godin, Isabel Plasencia-Fernandez, Martin Cottet, Annie Castonguay, Feng Wang, Chiara Salio, Nicolas Doyon, Adalberto Merighi, Yves De Koninck
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/4ac2ed6526874748a22aff64150835ea
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https://doaj.org/article/4ac2ed6526874748a22aff64150835ea

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