PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections

Epithelial host defense to rhinovirus infections is enhanced by targeting the mitochondrial metabolic regulator, PGC-1a. Using metabolomics and proteomics, Michi et al show that human airway epithelial cells mount a barrier-protective early glycolysis-shift in response to rhinovirus, and that by tar...

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Autores principales: Aubrey N. Michi, Bryan G. Yipp, Antoine Dufour, Fernando Lopes, David Proud
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4ad81efea5d74dc78473dc5ffdbcd650
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