PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections

Epithelial host defense to rhinovirus infections is enhanced by targeting the mitochondrial metabolic regulator, PGC-1a. Using metabolomics and proteomics, Michi et al show that human airway epithelial cells mount a barrier-protective early glycolysis-shift in response to rhinovirus, and that by tar...

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Autores principales:	Aubrey N. Michi, Bryan G. Yipp, Antoine Dufour, Fernando Lopes, David Proud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4ad81efea5d74dc78473dc5ffdbcd650
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spelling	oai:doaj.org-article:4ad81efea5d74dc78473dc5ffdbcd6502021-12-02T17:40:25ZPGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections10.1038/s41467-021-23925-z2041-1723https://doaj.org/article/4ad81efea5d74dc78473dc5ffdbcd6502021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23925-zhttps://doaj.org/toc/2041-1723Epithelial host defense to rhinovirus infections is enhanced by targeting the mitochondrial metabolic regulator, PGC-1a. Using metabolomics and proteomics, Michi et al show that human airway epithelial cells mount a barrier-protective early glycolysis-shift in response to rhinovirus, and that by targeting PGC-1a early in infection, epithelial barrier function, viral defense and pathology are improved.Aubrey N. MichiBryan G. YippAntoine DufourFernando LopesDavid ProudNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aubrey N. Michi Bryan G. Yipp Antoine Dufour Fernando Lopes David Proud PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
description	Epithelial host defense to rhinovirus infections is enhanced by targeting the mitochondrial metabolic regulator, PGC-1a. Using metabolomics and proteomics, Michi et al show that human airway epithelial cells mount a barrier-protective early glycolysis-shift in response to rhinovirus, and that by targeting PGC-1a early in infection, epithelial barrier function, viral defense and pathology are improved.
format	article
author	Aubrey N. Michi Bryan G. Yipp Antoine Dufour Fernando Lopes David Proud
author_facet	Aubrey N. Michi Bryan G. Yipp Antoine Dufour Fernando Lopes David Proud
author_sort	Aubrey N. Michi
title	PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
title_short	PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
title_full	PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
title_fullStr	PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
title_full_unstemmed	PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
title_sort	pgc-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4ad81efea5d74dc78473dc5ffdbcd650
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PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections

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