Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

Glutamine metabolism is increased in proliferating cells under hypoxia potentially generating exceeding nitrogen. Here the authors show that under hypoxia a specific metabolic pathway is activated to push glutamine carbons and excess nitrogen via the reductive pathway to dihyroorotate which is then...

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Bibliographic Details
Main Authors: Yuanyuan Wang, Changsen Bai, Yuxia Ruan, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang, Binghui Li
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/4af948245c3a4fd4b6c1e1144b804ba7
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