Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

Glutamine metabolism is increased in proliferating cells under hypoxia potentially generating exceeding nitrogen. Here the authors show that under hypoxia a specific metabolic pathway is activated to push glutamine carbons and excess nitrogen via the reductive pathway to dihyroorotate which is then...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuanyuan Wang, Changsen Bai, Yuxia Ruan, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang, Binghui Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4af948245c3a4fd4b6c1e1144b804ba7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4af948245c3a4fd4b6c1e1144b804ba7
record_format	dspace
spelling	oai:doaj.org-article:4af948245c3a4fd4b6c1e1144b804ba72021-12-02T16:50:57ZCoordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia10.1038/s41467-018-08033-92041-1723https://doaj.org/article/4af948245c3a4fd4b6c1e1144b804ba72019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08033-9https://doaj.org/toc/2041-1723Glutamine metabolism is increased in proliferating cells under hypoxia potentially generating exceeding nitrogen. Here the authors show that under hypoxia a specific metabolic pathway is activated to push glutamine carbons and excess nitrogen via the reductive pathway to dihyroorotate which is then secreted by the cells and that such pathway is necessary for tumor growth.Yuanyuan WangChangsen BaiYuxia RuanMiao LiuQiaoyun ChuLi QiuChuanzhen YangBinghui LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuanyuan Wang Changsen Bai Yuxia Ruan Miao Liu Qiaoyun Chu Li Qiu Chuanzhen Yang Binghui Li Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
description	Glutamine metabolism is increased in proliferating cells under hypoxia potentially generating exceeding nitrogen. Here the authors show that under hypoxia a specific metabolic pathway is activated to push glutamine carbons and excess nitrogen via the reductive pathway to dihyroorotate which is then secreted by the cells and that such pathway is necessary for tumor growth.
format	article
author	Yuanyuan Wang Changsen Bai Yuxia Ruan Miao Liu Qiaoyun Chu Li Qiu Chuanzhen Yang Binghui Li
author_facet	Yuanyuan Wang Changsen Bai Yuxia Ruan Miao Liu Qiaoyun Chu Li Qiu Chuanzhen Yang Binghui Li
author_sort	Yuanyuan Wang
title	Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
title_short	Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
title_full	Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
title_fullStr	Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
title_full_unstemmed	Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
title_sort	coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4af948245c3a4fd4b6c1e1144b804ba7
work_keys_str_mv	AT yuanyuanwang coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT changsenbai coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT yuxiaruan coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT miaoliu coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT qiaoyunchu coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT liqiu coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT chuanzhenyang coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia AT binghuili coordinativemetabolismofglutaminecarbonandnitrogeninproliferatingcancercellsunderhypoxia
_version_	1718382974977703936

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

Ejemplares similares