Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction

Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction

Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Previous work in our group has demonstrated that overweight/obese OAC patients have better responses to neoadjuvant therapy, but the underlying mechanisms are unknown. Unravelling the immune–metabolic signatures of a...

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Bibliographic Details
Main Authors: Aisling B. Heeran, Jessica McCready, Margaret R. Dunne, Noel E. Donlon, Timothy S. Nugent, Anshul Bhardwaj, Kathleen A. J. Mitchelson, Amy M. Buckley, Narayanasamy Ravi, Helen M. Roche, John V. Reynolds, Niamh Lynam-Lennon, Jacintha O’Sullivan
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
adipose tissue
immune mediators
immune-metabolic signature
metabolism
oesophageal cancer
Microbiology
QR1-502
Online Access:https://doaj.org/article/4b17fa7c7aa34e3fb57f33a4372a340f
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