Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/4b3a136e97e9418588502ed7dece3071 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:4b3a136e97e9418588502ed7dece3071 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:4b3a136e97e9418588502ed7dece30712021-12-02T14:01:26ZSerine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy10.1038/s41467-020-20223-y2041-1723https://doaj.org/article/4b3a136e97e9418588502ed7dece30712021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20223-yhttps://doaj.org/toc/2041-1723Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models.Mylène TajanMarc HennequartEric C. CheungFabio ZaniAndreas K. HockNathalie LegraveOliver D. K. MaddocksRachel A. RidgwayDimitris AthineosAlejandro Suárez-BonnetRobert L. LudwigLaura NovellasdemuntNikolaos AngelisVivian S. W. LiGeorgios VlachogiannisNicola ValeriNello MainolfiVipin SuriAdam FriedmanMark ManfrediKaren BlythOwen J. SansomKaren H. VousdenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mylène Tajan Marc Hennequart Eric C. Cheung Fabio Zani Andreas K. Hock Nathalie Legrave Oliver D. K. Maddocks Rachel A. Ridgway Dimitris Athineos Alejandro Suárez-Bonnet Robert L. Ludwig Laura Novellasdemunt Nikolaos Angelis Vivian S. W. Li Georgios Vlachogiannis Nicola Valeri Nello Mainolfi Vipin Suri Adam Friedman Mark Manfredi Karen Blyth Owen J. Sansom Karen H. Vousden Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| description |
Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models. |
| format |
article |
| author |
Mylène Tajan Marc Hennequart Eric C. Cheung Fabio Zani Andreas K. Hock Nathalie Legrave Oliver D. K. Maddocks Rachel A. Ridgway Dimitris Athineos Alejandro Suárez-Bonnet Robert L. Ludwig Laura Novellasdemunt Nikolaos Angelis Vivian S. W. Li Georgios Vlachogiannis Nicola Valeri Nello Mainolfi Vipin Suri Adam Friedman Mark Manfredi Karen Blyth Owen J. Sansom Karen H. Vousden |
| author_facet |
Mylène Tajan Marc Hennequart Eric C. Cheung Fabio Zani Andreas K. Hock Nathalie Legrave Oliver D. K. Maddocks Rachel A. Ridgway Dimitris Athineos Alejandro Suárez-Bonnet Robert L. Ludwig Laura Novellasdemunt Nikolaos Angelis Vivian S. W. Li Georgios Vlachogiannis Nicola Valeri Nello Mainolfi Vipin Suri Adam Friedman Mark Manfredi Karen Blyth Owen J. Sansom Karen H. Vousden |
| author_sort |
Mylène Tajan |
| title |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| title_short |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| title_full |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| title_fullStr |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| title_full_unstemmed |
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| title_sort |
serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/4b3a136e97e9418588502ed7dece3071 |
| work_keys_str_mv |
AT mylenetajan serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT marchennequart serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT ericccheung serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT fabiozani serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT andreaskhock serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT nathalielegrave serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT oliverdkmaddocks serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT rachelaridgway serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT dimitrisathineos serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT alejandrosuarezbonnet serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT robertlludwig serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT lauranovellasdemunt serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT nikolaosangelis serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT vivianswli serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT georgiosvlachogiannis serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT nicolavaleri serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT nellomainolfi serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT vipinsuri serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT adamfriedman serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT markmanfredi serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT karenblyth serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT owenjsansom serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy AT karenhvousden serinesynthesispathwayinhibitioncooperateswithdietaryserineandglycinelimitationforcancertherapy |
| _version_ |
1718392139004510208 |