A licensing step links AID to transcription elongation for mutagenesis in B cells

Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcription elongation to license AID for specific mutag...

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Autores principales: Stephen P. Methot, Ludivine C. Litzler, Poorani Ganesh Subramani, Anil K. Eranki, Heather Fifield, Anne-Marie Patenaude, Julian C. Gilmore, Gabriel E. Santiago, Halil Bagci, Jean-François Côté, Mani Larijani, Ramiro E. Verdun, Javier M. Di Noia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
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