A licensing step links AID to transcription elongation for mutagenesis in B cells

A licensing step links AID to transcription elongation for mutagenesis in B cells

Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcription elongation to license AID for specific mutag...

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Autores principales: Stephen P. Methot, Ludivine C. Litzler, Poorani Ganesh Subramani, Anil K. Eranki, Heather Fifield, Anne-Marie Patenaude, Julian C. Gilmore, Gabriel E. Santiago, Halil Bagci, Jean-François Côté, Mani Larijani, Ramiro E. Verdun, Javier M. Di Noia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
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spelling oai:doaj.org-article:4b68ae1b781848de928edd5a95b1ea1e2021-12-02T14:40:02ZA licensing step links AID to transcription elongation for mutagenesis in B cells10.1038/s41467-018-03387-62041-1723https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03387-6https://doaj.org/toc/2041-1723Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcription elongation to license AID for specific mutagenesis in B cells.Stephen P. MethotLudivine C. LitzlerPoorani Ganesh SubramaniAnil K. ErankiHeather FifieldAnne-Marie PatenaudeJulian C. GilmoreGabriel E. SantiagoHalil BagciJean-François CôtéMani LarijaniRamiro E. VerdunJavier M. Di NoiaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stephen P. Methot
Ludivine C. Litzler
Poorani Ganesh Subramani
Anil K. Eranki
Heather Fifield
Anne-Marie Patenaude
Julian C. Gilmore
Gabriel E. Santiago
Halil Bagci
Jean-François Côté
Mani Larijani
Ramiro E. Verdun
Javier M. Di Noia
A licensing step links AID to transcription elongation for mutagenesis in B cells
description Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcription elongation to license AID for specific mutagenesis in B cells.
format article
author Stephen P. Methot
Ludivine C. Litzler
Poorani Ganesh Subramani
Anil K. Eranki
Heather Fifield
Anne-Marie Patenaude
Julian C. Gilmore
Gabriel E. Santiago
Halil Bagci
Jean-François Côté
Mani Larijani
Ramiro E. Verdun
Javier M. Di Noia
author_facet Stephen P. Methot
Ludivine C. Litzler
Poorani Ganesh Subramani
Anil K. Eranki
Heather Fifield
Anne-Marie Patenaude
Julian C. Gilmore
Gabriel E. Santiago
Halil Bagci
Jean-François Côté
Mani Larijani
Ramiro E. Verdun
Javier M. Di Noia
author_sort Stephen P. Methot
title A licensing step links AID to transcription elongation for mutagenesis in B cells
title_short A licensing step links AID to transcription elongation for mutagenesis in B cells
title_full A licensing step links AID to transcription elongation for mutagenesis in B cells
title_fullStr A licensing step links AID to transcription elongation for mutagenesis in B cells
title_full_unstemmed A licensing step links AID to transcription elongation for mutagenesis in B cells
title_sort licensing step links aid to transcription elongation for mutagenesis in b cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
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