Hit and go CAS9 delivered through a lentiviral based self-limiting circuit

Hit and go CAS9 delivered through a lentiviral based self-limiting circuit

While CRISPR-Cas9 is a powerful technology, it’sin vivoapplication can be limited by unwanted off-target editing events. Here the authors present SLiCES, a self-limiting Cas9 circuit to enhance editing by preventing residual nuclease activity.

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Autores principales: Gianluca Petris, Antonio Casini, Claudia Montagna, Francesca Lorenzin, Davide Prandi, Alessandro Romanel, Jacopo Zasso, Luciano Conti, Francesca Demichelis, Anna Cereseto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/4b75436d9fde4cdeb8ae9bd081b0bd4f
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https://doaj.org/article/4b75436d9fde4cdeb8ae9bd081b0bd4f

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