Hit and go CAS9 delivered through a lentiviral based self-limiting circuit

While CRISPR-Cas9 is a powerful technology, it’sin vivoapplication can be limited by unwanted off-target editing events. Here the authors present SLiCES, a self-limiting Cas9 circuit to enhance editing by preventing residual nuclease activity.

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Detalles Bibliográficos
Autores principales:	Gianluca Petris, Antonio Casini, Claudia Montagna, Francesca Lorenzin, Davide Prandi, Alessandro Romanel, Jacopo Zasso, Luciano Conti, Francesca Demichelis, Anna Cereseto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4b75436d9fde4cdeb8ae9bd081b0bd4f
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spelling	oai:doaj.org-article:4b75436d9fde4cdeb8ae9bd081b0bd4f2021-12-02T14:41:22ZHit and go CAS9 delivered through a lentiviral based self-limiting circuit10.1038/ncomms153342041-1723https://doaj.org/article/4b75436d9fde4cdeb8ae9bd081b0bd4f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15334https://doaj.org/toc/2041-1723While CRISPR-Cas9 is a powerful technology, it’sin vivoapplication can be limited by unwanted off-target editing events. Here the authors present SLiCES, a self-limiting Cas9 circuit to enhance editing by preventing residual nuclease activity.Gianluca PetrisAntonio CasiniClaudia MontagnaFrancesca LorenzinDavide PrandiAlessandro RomanelJacopo ZassoLuciano ContiFrancesca DemichelisAnna CeresetoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gianluca Petris Antonio Casini Claudia Montagna Francesca Lorenzin Davide Prandi Alessandro Romanel Jacopo Zasso Luciano Conti Francesca Demichelis Anna Cereseto Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
description	While CRISPR-Cas9 is a powerful technology, it’sin vivoapplication can be limited by unwanted off-target editing events. Here the authors present SLiCES, a self-limiting Cas9 circuit to enhance editing by preventing residual nuclease activity.
format	article
author	Gianluca Petris Antonio Casini Claudia Montagna Francesca Lorenzin Davide Prandi Alessandro Romanel Jacopo Zasso Luciano Conti Francesca Demichelis Anna Cereseto
author_facet	Gianluca Petris Antonio Casini Claudia Montagna Francesca Lorenzin Davide Prandi Alessandro Romanel Jacopo Zasso Luciano Conti Francesca Demichelis Anna Cereseto
author_sort	Gianluca Petris
title	Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
title_short	Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
title_full	Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
title_fullStr	Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
title_full_unstemmed	Hit and go CAS9 delivered through a lentiviral based self-limiting circuit
title_sort	hit and go cas9 delivered through a lentiviral based self-limiting circuit
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4b75436d9fde4cdeb8ae9bd081b0bd4f
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Hit and go CAS9 delivered through a lentiviral based self-limiting circuit

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