Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab

Abstract Anti-PD-L1 antibodies benefit many cancer patients, even those with “non-inflamed tumor”. Determining which patients will benefit remains an important clinical goal. In a non-inflamed tumor mouse model, we found that PD-L1 was highly expressed on antigen-presenting cells (APCs) especially o...

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Auteurs principaux: Toshiki Iwai, Masamichi Sugimoto, Namrata S. Patil, Daniel Bower, Miho Suzuki, Chie Kato, Keigo Yorozu, Mitsue Kurasawa, David S. Shames, Osamu Kondoh
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/4b94adbd323b4bf69ee418f876c26582
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