Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are proposed to counteract the post-translational modification of signaling molecules that activate the innate immune response. Here we ex...
Guardado en:
Autores principales: | Kiira Ratia, Andrew Kilianski, Yahira M Baez-Santos, Susan C Baker, Andrew Mesecar |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4ba3475c68814eeabbd9182648e77f5b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Identification of ebselen and its analogues as potent covalent inhibitors of papain-like protease from SARS-CoV-2
por: Ewelina Weglarz-Tomczak, et al.
Publicado: (2021) -
Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling.
por: Li Sun, et al.
Publicado: (2012) -
Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
por: Keijun Kakihara, et al.
Publicado: (2021) -
Characterization of the Trans-Epithelial Transport of Green Tea (<i>C. sinensis</i>) Catechin Extracts with In Vitro Inhibitory Effect against the SARS-CoV-2 Papain-like Protease Activity
por: Carmela Maria Montone, et al.
Publicado: (2021) -
<i>In Silico</i> Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking, ADMET, Toxicity and DFT Studies
por: Mohamed S. Alesawy, et al.
Publicado: (2021)