Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila

Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GS...

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Bibliographic Details
Main Authors: Ying Liu, Qinglan Ge, Brian Chan, Hanhan Liu, Shree Ram Singh, Jacob Manley, Jae Lee, Ann Marie Weideman, Gerald Hou, Steven X. Hou
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/4bacdc24e3e94f74b5fe7c8b9d8f0369
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Summary:Both intrinsic and external signals regulate stem cell fate. Here, the authors perform a genome-wide RNAi screen to identify regulators of testis germline stem cells (GSC) in Drosophila, finding more than half of the genes were external regulators and heterochromatin/cytokinesis proteins mediated GSC fate.