Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase

Various herpesvirus therapeutics target the viral DNA polymerase. Here, the authors present the crystal structure of herpesvirus polymerase in the elongating state with bound primer-template DNA and the broad-spectrum non-nucleoside inhibitor PNU-183792, which is of interest for further drug design.

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Autores principales: Robert P. Hayes, Mee Ra Heo, Mark Mason, John Reid, Christine Burlein, Kira A. Armacost, David M. Tellers, Izzat Raheem, Anthony W. Shaw, Edward Murray, Philip M. McKenna, Pravien Abeywickrema, Sujata Sharma, Stephen M. Soisson, Daniel Klein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/4bd96a2415b244b397a96da4a23966c4
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https://doaj.org/article/4bd96a2415b244b397a96da4a23966c4

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