DOT1L inhibitors block abnormal self-renewal induced by cohesin loss

DOT1L inhibitors block abnormal self-renewal induced by cohesin loss

Abstract Acute myeloid leukemia (AML) is a high-risk malignancy characterized by a diverse spectrum of somatic genetic alterations. The mechanisms by which these mutations contribute to leukemia development and how this informs the use of targeted therapies is critical to improving outcomes for pati...

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Main Authors: Katelyn E. Heimbruch, Joseph B. Fisher, Cary T. Stelloh, Emily Phillips, Michael H. Reimer, Adam J. Wargolet, Alison E. Meyer, Kirthi Pulakanti, Aaron D. Viny, Jessica J. Loppnow, Ross L. Levine, John Anto Pulikkan, Nan Zhu, Sridhar Rao
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/4bea0347dc9d49beb5298d2cdd70741f
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https://doaj.org/article/4bea0347dc9d49beb5298d2cdd70741f

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