ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

Macrophage stimulation by pathogen-associated molecular patterns (PAMPs) like lipopolysaccharide (LPS) or lipoteichoic acid (LTA) drives a proinflammatory phenotype and induces a metabolic reprogramming to sustain the cell’s function. Nevertheless, the relationship between metabolic shifts and gene...

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Autores principales: Anna Santarsiero, Paolo Convertini, Simona Todisco, Ciro L. Pierri, Anna De Grassi, Niamh C. Williams, Dominga Iacobazzi, Giulio De Stefano, Luke A. J. O’Neill, Vittoria Infantino
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
ACLY
inflammation
macrophages
nuclear translocation
NF-κB
p65 acetylation
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/4c0373f557ba404185f721458bb1f4e7
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https://doaj.org/article/4c0373f557ba404185f721458bb1f4e7

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