Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones

Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones

Tricyclo[5.2.1.01,5]decanes are often found in bioactive natural products; however, their synthesis poses significant challenges. Here, the authors report a nickel-catalyzed asymmetric domino cyclization of enynones, providing a rapid and modular synthesis of bridged tricyclo[5.2.1.01,5]decane skele...

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Autores principales: Jiachang Chen, Yiming Wang, Zhengtian Ding, Wangqing Kong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/4c273223437a4e4692ee2bb0808ecbd9
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spelling oai:doaj.org-article:4c273223437a4e4692ee2bb0808ecbd92021-12-02T15:33:53ZSynthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones10.1038/s41467-020-15837-12041-1723https://doaj.org/article/4c273223437a4e4692ee2bb0808ecbd92020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15837-1https://doaj.org/toc/2041-1723Tricyclo[5.2.1.01,5]decanes are often found in bioactive natural products; however, their synthesis poses significant challenges. Here, the authors report a nickel-catalyzed asymmetric domino cyclization of enynones, providing a rapid and modular synthesis of bridged tricyclo[5.2.1.01,5]decane skeletons.Jiachang ChenYiming WangZhengtian DingWangqing KongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiachang Chen
Yiming Wang
Zhengtian Ding
Wangqing Kong
Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
description Tricyclo[5.2.1.01,5]decanes are often found in bioactive natural products; however, their synthesis poses significant challenges. Here, the authors report a nickel-catalyzed asymmetric domino cyclization of enynones, providing a rapid and modular synthesis of bridged tricyclo[5.2.1.01,5]decane skeletons.
format article
author Jiachang Chen
Yiming Wang
Zhengtian Ding
Wangqing Kong
author_facet Jiachang Chen
Yiming Wang
Zhengtian Ding
Wangqing Kong
author_sort Jiachang Chen
title Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
title_short Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
title_full Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
title_fullStr Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
title_full_unstemmed Synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
title_sort synthesis of bridged tricyclo[5.2.1.01,5]decanes via nickel-catalyzed asymmetric domino cyclization of enynones
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/4c273223437a4e4692ee2bb0808ecbd9
work_keys_str_mv AT jiachangchen synthesisofbridgedtricyclo521015decanesvianickelcatalyzedasymmetricdominocyclizationofenynones
AT yimingwang synthesisofbridgedtricyclo521015decanesvianickelcatalyzedasymmetricdominocyclizationofenynones
AT zhengtianding synthesisofbridgedtricyclo521015decanesvianickelcatalyzedasymmetricdominocyclizationofenynones
AT wangqingkong synthesisofbridgedtricyclo521015decanesvianickelcatalyzedasymmetricdominocyclizationofenynones
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