Structural and regulatory diversity shape HLA-C protein expression levels

HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-bi...

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Autores principales:	Gurman Kaur, Stephanie Gras, Jesse I. Mobbs, Julian P. Vivian, Adrian Cortes, Thomas Barber, Subita Balaram Kuttikkatte, Lise Torp Jensen, Kathrine E. Attfield, Calliope A. Dendrou, Mary Carrington, Gil McVean, Anthony W. Purcell, Jamie Rossjohn, Lars Fugger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c28f2c443c84beb93aec319db427db0
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spelling	oai:doaj.org-article:4c28f2c443c84beb93aec319db427db02021-12-02T17:06:02ZStructural and regulatory diversity shape HLA-C protein expression levels10.1038/ncomms159242041-1723https://doaj.org/article/4c28f2c443c84beb93aec319db427db02017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15924https://doaj.org/toc/2041-1723HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-binding cleft and diversity of peptides bound by HLA-C molecules.Gurman KaurStephanie GrasJesse I. MobbsJulian P. VivianAdrian CortesThomas BarberSubita Balaram KuttikkatteLise Torp JensenKathrine E. AttfieldCalliope A. DendrouMary CarringtonGil McVeanAnthony W. PurcellJamie RossjohnLars FuggerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gurman Kaur Stephanie Gras Jesse I. Mobbs Julian P. Vivian Adrian Cortes Thomas Barber Subita Balaram Kuttikkatte Lise Torp Jensen Kathrine E. Attfield Calliope A. Dendrou Mary Carrington Gil McVean Anthony W. Purcell Jamie Rossjohn Lars Fugger Structural and regulatory diversity shape HLA-C protein expression levels
description	HLA-C expression levels correlate with immune responses to pathogens and autoimmunity, and vary in an allele-specific manner across individuals. Here the authors identify factors that drive differential expression of HLA-C allomorphs at the cell surface, and influence the structure of the peptide-binding cleft and diversity of peptides bound by HLA-C molecules.
format	article
author	Gurman Kaur Stephanie Gras Jesse I. Mobbs Julian P. Vivian Adrian Cortes Thomas Barber Subita Balaram Kuttikkatte Lise Torp Jensen Kathrine E. Attfield Calliope A. Dendrou Mary Carrington Gil McVean Anthony W. Purcell Jamie Rossjohn Lars Fugger
author_facet	Gurman Kaur Stephanie Gras Jesse I. Mobbs Julian P. Vivian Adrian Cortes Thomas Barber Subita Balaram Kuttikkatte Lise Torp Jensen Kathrine E. Attfield Calliope A. Dendrou Mary Carrington Gil McVean Anthony W. Purcell Jamie Rossjohn Lars Fugger
author_sort	Gurman Kaur
title	Structural and regulatory diversity shape HLA-C protein expression levels
title_short	Structural and regulatory diversity shape HLA-C protein expression levels
title_full	Structural and regulatory diversity shape HLA-C protein expression levels
title_fullStr	Structural and regulatory diversity shape HLA-C protein expression levels
title_full_unstemmed	Structural and regulatory diversity shape HLA-C protein expression levels
title_sort	structural and regulatory diversity shape hla-c protein expression levels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4c28f2c443c84beb93aec319db427db0
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Structural and regulatory diversity shape HLA-C protein expression levels

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