PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
Acetylation of p53 is critical for its transcriptional activity and its tumour suppressive function. Here, the authors show that PBRM1 is a reader protein for p53′s C-terminal domain acetylation on lysine 382 through its bromodomain 4 and that mutations in this domain leads to compromised tumour sup...
Guardado en:
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:4c56454ffebd47ce98598764f25ff35c |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:4c56454ffebd47ce98598764f25ff35c2021-12-02T14:39:02ZPBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth10.1038/s41467-019-13608-12041-1723https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13608-1https://doaj.org/toc/2041-1723Acetylation of p53 is critical for its transcriptional activity and its tumour suppressive function. Here, the authors show that PBRM1 is a reader protein for p53′s C-terminal domain acetylation on lysine 382 through its bromodomain 4 and that mutations in this domain leads to compromised tumour suppressive function and renal tumour growth.Weijia CaiLiya SuLili LiaoZongzhi Z. LiuLauren LangbeinEssel DulaimiJoseph R. TestaRobert G. UzzoZhijiu ZhongWei JiangQin YanQing ZhangHaifeng YangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Weijia Cai Liya Su Lili Liao Zongzhi Z. Liu Lauren Langbein Essel Dulaimi Joseph R. Testa Robert G. Uzzo Zhijiu Zhong Wei Jiang Qin Yan Qing Zhang Haifeng Yang PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
description |
Acetylation of p53 is critical for its transcriptional activity and its tumour suppressive function. Here, the authors show that PBRM1 is a reader protein for p53′s C-terminal domain acetylation on lysine 382 through its bromodomain 4 and that mutations in this domain leads to compromised tumour suppressive function and renal tumour growth. |
format |
article |
author |
Weijia Cai Liya Su Lili Liao Zongzhi Z. Liu Lauren Langbein Essel Dulaimi Joseph R. Testa Robert G. Uzzo Zhijiu Zhong Wei Jiang Qin Yan Qing Zhang Haifeng Yang |
author_facet |
Weijia Cai Liya Su Lili Liao Zongzhi Z. Liu Lauren Langbein Essel Dulaimi Joseph R. Testa Robert G. Uzzo Zhijiu Zhong Wei Jiang Qin Yan Qing Zhang Haifeng Yang |
author_sort |
Weijia Cai |
title |
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
title_short |
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
title_full |
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
title_fullStr |
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
title_full_unstemmed |
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
title_sort |
pbrm1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/4c56454ffebd47ce98598764f25ff35c |
work_keys_str_mv |
AT weijiacai pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT liyasu pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT lililiao pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT zongzhizliu pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT laurenlangbein pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT esseldulaimi pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT josephrtesta pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT robertguzzo pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT zhijiuzhong pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT weijiang pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT qinyan pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT qingzhang pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth AT haifengyang pbrm1actsasap53lysineacetylationreadertosuppressrenaltumorgrowth |
_version_ |
1718390770035064832 |