PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and subsequent collapse of chromosome alignment....

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Owen Addis Jones, Ankana Tiwari, Tomisin Olukoga, Alex Herbert, Kok-Lung Chan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/4c92908d8a3140aca54c75ace50338bb
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!