PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and subsequent collapse of chromosome alignment....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Owen Addis Jones, Ankana Tiwari, Tomisin Olukoga, Alex Herbert, Kok-Lung Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4c92908d8a3140aca54c75ace50338bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4c92908d8a3140aca54c75ace50338bb
record_format	dspace
spelling	oai:doaj.org-article:4c92908d8a3140aca54c75ace50338bb2021-12-02T14:35:36ZPLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling10.1038/s41467-019-10938-y2041-1723https://doaj.org/article/4c92908d8a3140aca54c75ace50338bb2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10938-yhttps://doaj.org/toc/2041-1723The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and subsequent collapse of chromosome alignment.Owen Addis JonesAnkana TiwariTomisin OlukogaAlex HerbertKok-Lung ChanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Owen Addis Jones Ankana Tiwari Tomisin Olukoga Alex Herbert Kok-Lung Chan PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling
description	The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and subsequent collapse of chromosome alignment.
format	article
author	Owen Addis Jones Ankana Tiwari Tomisin Olukoga Alex Herbert Kok-Lung Chan
author_facet	Owen Addis Jones Ankana Tiwari Tomisin Olukoga Alex Herbert Kok-Lung Chan
author_sort	Owen Addis Jones
title	PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling
title_short	PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling
title_full	PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling
title_fullStr	PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling
title_full_unstemmed	PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling
title_sort	plk1 facilitates chromosome biorientation by suppressing centromere disintegration driven by blm-mediated unwinding and spindle pulling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4c92908d8a3140aca54c75ace50338bb
work_keys_str_mv	AT owenaddisjones plk1facilitateschromosomebiorientationbysuppressingcentromeredisintegrationdrivenbyblmmediatedunwindingandspindlepulling AT ankanatiwari plk1facilitateschromosomebiorientationbysuppressingcentromeredisintegrationdrivenbyblmmediatedunwindingandspindlepulling AT tomisinolukoga plk1facilitateschromosomebiorientationbysuppressingcentromeredisintegrationdrivenbyblmmediatedunwindingandspindlepulling AT alexherbert plk1facilitateschromosomebiorientationbysuppressingcentromeredisintegrationdrivenbyblmmediatedunwindingandspindlepulling AT koklungchan plk1facilitateschromosomebiorientationbysuppressingcentromeredisintegrationdrivenbyblmmediatedunwindingandspindlepulling
_version_	1718391068910682112

PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pulling

Ejemplares similares