A disorder-induced domino-like destabilization mechanism governs the folding and functional dynamics of the repeat protein IκBα.

The stability of the repeat protein IκBα, a transcriptional inhibitor in mammalian cells, is critical in the functioning of the NF-κB signaling module implicated in an array of cellular processes, including cell growth, disease, immunity and apoptosis. Structurally, IκBα is complex, with both ordere...

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Autores principales: Srinivasan Sivanandan, Athi N Naganathan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/4ca32e533e98449c8fa976f728445569
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