Diverse genetic error modes constrain large-scale bio-based production

The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.

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Autores principales: Peter Rugbjerg, Nils Myling-Petersen, Andreas Porse, Kira Sarup-Lytzen, Morten O. A. Sommer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd7
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