Diverse genetic error modes constrain large-scale bio-based production

The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.

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Autores principales:	Peter Rugbjerg, Nils Myling-Petersen, Andreas Porse, Kira Sarup-Lytzen, Morten O. A. Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd7
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spelling	oai:doaj.org-article:4caa8177d5ef40bd92bbb5f435868dd72021-12-02T16:50:08ZDiverse genetic error modes constrain large-scale bio-based production10.1038/s41467-018-03232-w2041-1723https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd72018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03232-whttps://doaj.org/toc/2041-1723The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.Peter RugbjergNils Myling-PetersenAndreas PorseKira Sarup-LytzenMorten O. A. SommerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter Rugbjerg Nils Myling-Petersen Andreas Porse Kira Sarup-Lytzen Morten O. A. Sommer Diverse genetic error modes constrain large-scale bio-based production
description	The declining performance of scale-up bioreactor cultures is commonly attributed to phenotypic and physical heterogeneities. Here, the authors reveal multiple recurring intra-pathway error modes that limit engineered E. coli mevalonic acid production over time- and industrial-scale fermentations.
format	article
author	Peter Rugbjerg Nils Myling-Petersen Andreas Porse Kira Sarup-Lytzen Morten O. A. Sommer
author_facet	Peter Rugbjerg Nils Myling-Petersen Andreas Porse Kira Sarup-Lytzen Morten O. A. Sommer
author_sort	Peter Rugbjerg
title	Diverse genetic error modes constrain large-scale bio-based production
title_short	Diverse genetic error modes constrain large-scale bio-based production
title_full	Diverse genetic error modes constrain large-scale bio-based production
title_fullStr	Diverse genetic error modes constrain large-scale bio-based production
title_full_unstemmed	Diverse genetic error modes constrain large-scale bio-based production
title_sort	diverse genetic error modes constrain large-scale bio-based production
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4caa8177d5ef40bd92bbb5f435868dd7
work_keys_str_mv	AT peterrugbjerg diversegeneticerrormodesconstrainlargescalebiobasedproduction AT nilsmylingpetersen diversegeneticerrormodesconstrainlargescalebiobasedproduction AT andreasporse diversegeneticerrormodesconstrainlargescalebiobasedproduction AT kirasaruplytzen diversegeneticerrormodesconstrainlargescalebiobasedproduction AT mortenoasommer diversegeneticerrormodesconstrainlargescalebiobasedproduction
_version_	1718383096741494784

Diverse genetic error modes constrain large-scale bio-based production

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