Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population.

<h4>Background</h4>Albeit several studies pointed out the pivotal role that CD4+T cells have in Multiple Sclerosis, the CD8+ T cells involvement in the pathology is still in its early phases of investigation. Proteasome degradation is the key step in the production of MHC class I-restric...

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Auteurs principaux: Michele Mishto, Elena Bellavista, Claudia Ligorio, Kathrin Textoris-Taube, Aurelia Santoro, Mara Giordano, Sandra D'Alfonso, Florinda Listì, Benedetta Nacmias, Elena Cellini, Maurizio Leone, Luigi M E Grimaldi, Chiara Fenoglio, Federica Esposito, Filippo Martinelli-Boneschi, Daniela Galimberti, Elio Scarpini, Ulrike Seifert, Maria Pia Amato, Calogero Caruso, Maria P Foschini, Peter M Kloetzel, Claudio Franceschi
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2010
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/4cb4cbf2336142ff9d2394e21649e691
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https://doaj.org/article/4cb4cbf2336142ff9d2394e21649e691

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