Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.

This study investigated the behavioural and brain responses towards conditioned flavours with different hedonic values in juvenile pigs. Twelve 30-kg pigs were given four three-day conditioning sessions: they received three different flavoured meals paired with intraduodenal (i.d.) infusions of 15%...

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Autores principales:	Caroline Clouard, Mélanie Jouhanneau, Marie-Christine Meunier-Salaün, Charles-Henri Malbert, David Val-Laillet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4cbbf9394e9a4095b11c5cf9d5a2fc27
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spelling	oai:doaj.org-article:4cbbf9394e9a4095b11c5cf9d5a2fc272021-11-18T07:17:11ZExposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.1932-620310.1371/journal.pone.0037968https://doaj.org/article/4cbbf9394e9a4095b11c5cf9d5a2fc272012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22685528/?tool=EBIhttps://doaj.org/toc/1932-6203This study investigated the behavioural and brain responses towards conditioned flavours with different hedonic values in juvenile pigs. Twelve 30-kg pigs were given four three-day conditioning sessions: they received three different flavoured meals paired with intraduodenal (i.d.) infusions of 15% glucose (F(Glu)), lithium chloride (F(LiCl)), or saline (control treatment, F(NaCl)). One and five weeks later, the animals were subjected to three two-choice feeding tests without reinforcement to check the acquisition of a conditioned flavour preference or aversion. In between, the anaesthetised pigs were subjected to three (18)FDG PET brain imaging coupled with an olfactogustatory stimulation with the conditioned flavours. During conditioning, the pigs spent more time lying inactive, and investigated their environment less after the F(LiCl) than the F(NaCl) or F(Glu) meals. During the two-choice tests performed one and five weeks later, the F(NaCl) and F(Glu) foods were significantly preferred over the F(LICl) food even in the absence of i.d. infusions. Surprisingly, the F(NaCl) food was also preferred over the F(Glu) food during the first test only, suggesting that, while LiCl i.d. infusions led to a strong flavour aversion, glucose infusions failed to induce flavour preference. As for brain imaging results, exposure to aversive or less preferred flavours triggered global deactivation of the prefrontal cortex, specific activation of the posterior cingulate cortex, as well as asymmetric brain responses in the basal nuclei and the temporal gyrus. In conclusion, postingestive visceral stimuli can modulate the flavour/food hedonism and further feeding choices. Exposure to flavours with different hedonic values induced metabolism differences in neural circuits known to be involved in humans in the characterization of food palatability, feeding motivation, reward expectation, and more generally in the regulation of food intake.Caroline ClouardMélanie JouhanneauMarie-Christine Meunier-SalaünCharles-Henri MalbertDavid Val-LailletPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37968 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline Clouard Mélanie Jouhanneau Marie-Christine Meunier-Salaün Charles-Henri Malbert David Val-Laillet Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
description	This study investigated the behavioural and brain responses towards conditioned flavours with different hedonic values in juvenile pigs. Twelve 30-kg pigs were given four three-day conditioning sessions: they received three different flavoured meals paired with intraduodenal (i.d.) infusions of 15% glucose (F(Glu)), lithium chloride (F(LiCl)), or saline (control treatment, F(NaCl)). One and five weeks later, the animals were subjected to three two-choice feeding tests without reinforcement to check the acquisition of a conditioned flavour preference or aversion. In between, the anaesthetised pigs were subjected to three (18)FDG PET brain imaging coupled with an olfactogustatory stimulation with the conditioned flavours. During conditioning, the pigs spent more time lying inactive, and investigated their environment less after the F(LiCl) than the F(NaCl) or F(Glu) meals. During the two-choice tests performed one and five weeks later, the F(NaCl) and F(Glu) foods were significantly preferred over the F(LICl) food even in the absence of i.d. infusions. Surprisingly, the F(NaCl) food was also preferred over the F(Glu) food during the first test only, suggesting that, while LiCl i.d. infusions led to a strong flavour aversion, glucose infusions failed to induce flavour preference. As for brain imaging results, exposure to aversive or less preferred flavours triggered global deactivation of the prefrontal cortex, specific activation of the posterior cingulate cortex, as well as asymmetric brain responses in the basal nuclei and the temporal gyrus. In conclusion, postingestive visceral stimuli can modulate the flavour/food hedonism and further feeding choices. Exposure to flavours with different hedonic values induced metabolism differences in neural circuits known to be involved in humans in the characterization of food palatability, feeding motivation, reward expectation, and more generally in the regulation of food intake.
format	article
author	Caroline Clouard Mélanie Jouhanneau Marie-Christine Meunier-Salaün Charles-Henri Malbert David Val-Laillet
author_facet	Caroline Clouard Mélanie Jouhanneau Marie-Christine Meunier-Salaün Charles-Henri Malbert David Val-Laillet
author_sort	Caroline Clouard
title	Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
title_short	Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
title_full	Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
title_fullStr	Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
title_full_unstemmed	Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
title_sort	exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/4cbbf9394e9a4095b11c5cf9d5a2fc27
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Exposures to conditioned flavours with different hedonic values induce contrasted behavioural and brain responses in pigs.

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