Interaction between <i>M. tuberculosis</i> Lineage and Human Genetic Variants Reveals Novel Pathway Associations with Severity of TB

Interaction between <i>M. tuberculosis</i> Lineage and Human Genetic Variants Reveals Novel Pathway Associations with Severity of TB

Tuberculosis (TB) remains a major public health threat globally, especially in sub-Saharan Africa. Both human and <i>Mycobacterium tuberculosis</i> (MTBC) genetic variation affect TB outcomes, but few studies have examined if and how the two genomes interact to affect disease. We hypothe...

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Autores principales: Michael L. McHenry, Eddie M. Wampande, Moses L. Joloba, LaShaunda L. Malone, Harriet Mayanja-Kizza, William S. Bush, W. Henry Boom, Scott M. Williams, Catherine M. Stein
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
tuberculosis severity
<i>M. tuberculosis</i>
population genetics
lineage-based GWAS
<i>M. tuberculosis</i>–human coevolution
Medicine
R
Acceso en línea:https://doaj.org/article/4ce8188910264aaebe58bdfde9f3c03f
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https://doaj.org/article/4ce8188910264aaebe58bdfde9f3c03f

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