Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liver-localized mitochondrial uncoupler OPC-163493, w...

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Autores principales: Naohide Kanemoto, Takashi Okamoto, Koji Tanabe, Takahiro Shimada, Hitomi Minoshima, Yuya Hidoh, Masashi Aoyama, Takashi Ban, Yusuke Kobayashi, Hikaru Ando, Yuki Inoue, Motohiro Itotani, Seiji Sato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4cf4897abcfc4f0d9a71c0c81db9eeb9
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https://doaj.org/article/4cf4897abcfc4f0d9a71c0c81db9eeb9

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