Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liver-localized mitochondrial uncoupler OPC-163493, w...

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Autores principales:	Naohide Kanemoto, Takashi Okamoto, Koji Tanabe, Takahiro Shimada, Hitomi Minoshima, Yuya Hidoh, Masashi Aoyama, Takashi Ban, Yusuke Kobayashi, Hikaru Ando, Yuki Inoue, Motohiro Itotani, Seiji Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4cf4897abcfc4f0d9a71c0c81db9eeb9
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spelling	oai:doaj.org-article:4cf4897abcfc4f0d9a71c0c81db9eeb92021-12-02T16:57:44ZAntidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler10.1038/s41467-019-09911-62041-1723https://doaj.org/article/4cf4897abcfc4f0d9a71c0c81db9eeb92019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09911-6https://doaj.org/toc/2041-1723Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liver-localized mitochondrial uncoupler OPC-163493, which leads to amelioration of diabetes and hypertension in several rodent disease models.Naohide KanemotoTakashi OkamotoKoji TanabeTakahiro ShimadaHitomi MinoshimaYuya HidohMasashi AoyamaTakashi BanYusuke KobayashiHikaru AndoYuki InoueMotohiro ItotaniSeiji SatoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naohide Kanemoto Takashi Okamoto Koji Tanabe Takahiro Shimada Hitomi Minoshima Yuya Hidoh Masashi Aoyama Takashi Ban Yusuke Kobayashi Hikaru Ando Yuki Inoue Motohiro Itotani Seiji Sato Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
description	Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liver-localized mitochondrial uncoupler OPC-163493, which leads to amelioration of diabetes and hypertension in several rodent disease models.
format	article
author	Naohide Kanemoto Takashi Okamoto Koji Tanabe Takahiro Shimada Hitomi Minoshima Yuya Hidoh Masashi Aoyama Takashi Ban Yusuke Kobayashi Hikaru Ando Yuki Inoue Motohiro Itotani Seiji Sato
author_facet	Naohide Kanemoto Takashi Okamoto Koji Tanabe Takahiro Shimada Hitomi Minoshima Yuya Hidoh Masashi Aoyama Takashi Ban Yusuke Kobayashi Hikaru Ando Yuki Inoue Motohiro Itotani Seiji Sato
author_sort	Naohide Kanemoto
title	Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
title_short	Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
title_full	Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
title_fullStr	Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
title_full_unstemmed	Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
title_sort	antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4cf4897abcfc4f0d9a71c0c81db9eeb9
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Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

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