Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

The N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechani...

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Bibliographic Details
Main Authors: Wendan Ren, Jiuwei Lu, Mengjiang Huang, Linfeng Gao, Dongxu Li, Gang Greg Wang, Jikui Song
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/4d0f1780040a49189c2e227179d984e8
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