Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

The N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechani...

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Autores principales: Wendan Ren, Jiuwei Lu, Mengjiang Huang, Linfeng Gao, Dongxu Li, Gang Greg Wang, Jikui Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4d0f1780040a49189c2e227179d984e8
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spelling oai:doaj.org-article:4d0f1780040a49189c2e227179d984e82021-12-02T15:35:29ZStructure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA10.1038/s41467-019-12923-x2041-1723https://doaj.org/article/4d0f1780040a49189c2e227179d984e82019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12923-xhttps://doaj.org/toc/2041-1723The N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechanisms that ensure substrate specificity.Wendan RenJiuwei LuMengjiang HuangLinfeng GaoDongxu LiGang Greg WangJikui SongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wendan Ren
Jiuwei Lu
Mengjiang Huang
Linfeng Gao
Dongxu Li
Gang Greg Wang
Jikui Song
Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
description The N6-methyladenosine (m6A) RNA modification is an evolutionarily conserved epitranscriptomic mechanism that impacts several cellular processes. Here the authors present a structure-function analysis of the ZCCHC4, 28S RNA-specific m6A methyltransferase, shedding light on its regulation and mechanisms that ensure substrate specificity.
format article
author Wendan Ren
Jiuwei Lu
Mengjiang Huang
Linfeng Gao
Dongxu Li
Gang Greg Wang
Jikui Song
author_facet Wendan Ren
Jiuwei Lu
Mengjiang Huang
Linfeng Gao
Dongxu Li
Gang Greg Wang
Jikui Song
author_sort Wendan Ren
title Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
title_short Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
title_full Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
title_fullStr Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
title_full_unstemmed Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA
title_sort structure and regulation of zcchc4 in m6a-methylation of 28s rrna
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4d0f1780040a49189c2e227179d984e8
work_keys_str_mv AT wendanren structureandregulationofzcchc4inm6amethylationof28srrna
AT jiuweilu structureandregulationofzcchc4inm6amethylationof28srrna
AT mengjianghuang structureandregulationofzcchc4inm6amethylationof28srrna
AT linfenggao structureandregulationofzcchc4inm6amethylationof28srrna
AT dongxuli structureandregulationofzcchc4inm6amethylationof28srrna
AT ganggregwang structureandregulationofzcchc4inm6amethylationof28srrna
AT jikuisong structureandregulationofzcchc4inm6amethylationof28srrna
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