The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-ĸB p65 nuclear translocation

Chronic inflammation is characterized by persisting leukocyte infiltration of the affected tissue, which is enabled by activated endothelial cells (ECs). Chronic inflammatory diseases remain a major pharmacotherapeutic challenge, and thus the search for novel drugs and drug targets is an ongoing dem...

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Autores principales: Luisa D. Burgers, Betty Luong, Yanfen Li, Matthias P. Fabritius, Stylianos Michalakis, Christoph A. Reichel, Rolf Müller, Robert Fürst
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/4d20bc27720141d9918bfdcaca1d4432
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