Integer programming-based method for designing synthetic metabolic networks by Minimum Reaction Insertion in a Boolean model.

In this paper, we consider the Minimum Reaction Insertion (MRI) problem for finding the minimum number of additional reactions from a reference metabolic network to a host metabolic network so that a target compound becomes producible in the revised host metabolic network in a Boolean model. Althoug...

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Autores principales: Wei Lu, Takeyuki Tamura, Jiangning Song, Tatsuya Akutsu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/4d242125653f4e2ab3ef0c1e5f75ddd6
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