HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors, by analysing methylation profiles, identify HOPX as a suppressor of metastasis in nasopharyngeal carcinoma: mechanistically HOPX inhibitsSNAILtranscription through deacetylation-mediated silencing.

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Autores principales: Xianyue Ren, Xiaojing Yang, Bin Cheng, Xiaozhong Chen, Tianpeng Zhang, Qingmei He, Bin Li, Yingqin Li, Xinran Tang, Xin Wen, Qian Zhong, Tiebang Kang, Musheng Zeng, Na Liu, Jun Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/4d4ea197e9e44305baa10870ac7c3417
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https://doaj.org/article/4d4ea197e9e44305baa10870ac7c3417

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