HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors, by analysing methylation profiles, identify HOPX as a suppressor of metastasis in nasopharyngeal carcinoma: mechanistically HOPX inhibitsSNAILtranscription through deacetylation-mediated silencing.

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Autores principales: Xianyue Ren, Xiaojing Yang, Bin Cheng, Xiaozhong Chen, Tianpeng Zhang, Qingmei He, Bin Li, Yingqin Li, Xinran Tang, Xin Wen, Qian Zhong, Tiebang Kang, Musheng Zeng, Na Liu, Jun Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/4d4ea197e9e44305baa10870ac7c3417
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spelling oai:doaj.org-article:4d4ea197e9e44305baa10870ac7c34172021-12-02T14:42:04ZHOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma10.1038/ncomms140532041-1723https://doaj.org/article/4d4ea197e9e44305baa10870ac7c34172017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14053https://doaj.org/toc/2041-1723HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors, by analysing methylation profiles, identify HOPX as a suppressor of metastasis in nasopharyngeal carcinoma: mechanistically HOPX inhibitsSNAILtranscription through deacetylation-mediated silencing.Xianyue RenXiaojing YangBin ChengXiaozhong ChenTianpeng ZhangQingmei HeBin LiYingqin LiXinran TangXin WenQian ZhongTiebang KangMusheng ZengNa LiuJun MaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xianyue Ren
Xiaojing Yang
Bin Cheng
Xiaozhong Chen
Tianpeng Zhang
Qingmei He
Bin Li
Yingqin Li
Xinran Tang
Xin Wen
Qian Zhong
Tiebang Kang
Musheng Zeng
Na Liu
Jun Ma
HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
description HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors, by analysing methylation profiles, identify HOPX as a suppressor of metastasis in nasopharyngeal carcinoma: mechanistically HOPX inhibitsSNAILtranscription through deacetylation-mediated silencing.
format article
author Xianyue Ren
Xiaojing Yang
Bin Cheng
Xiaozhong Chen
Tianpeng Zhang
Qingmei He
Bin Li
Yingqin Li
Xinran Tang
Xin Wen
Qian Zhong
Tiebang Kang
Musheng Zeng
Na Liu
Jun Ma
author_facet Xianyue Ren
Xiaojing Yang
Bin Cheng
Xiaozhong Chen
Tianpeng Zhang
Qingmei He
Bin Li
Yingqin Li
Xinran Tang
Xin Wen
Qian Zhong
Tiebang Kang
Musheng Zeng
Na Liu
Jun Ma
author_sort Xianyue Ren
title HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
title_short HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
title_full HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
title_fullStr HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
title_full_unstemmed HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
title_sort hopx hypermethylation promotes metastasis via activating snail transcription in nasopharyngeal carcinoma
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/4d4ea197e9e44305baa10870ac7c3417
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