Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage population...

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Autores principales:	Amine Toubal, Badr Kiaf, Lucie Beaudoin, Lucie Cagninacci, Moez Rhimi, Blandine Fruchet, Jennifer da Silva, Alexandra J. Corbett, Yannick Simoni, Olivier Lantz, Jamie Rossjohn, James McCluskey, Philippe Lesnik, Emmanuelle Maguin, Agnès Lehuen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4d64013defa34421b522dd3241d24d0d
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spelling	oai:doaj.org-article:4d64013defa34421b522dd3241d24d0d2021-12-02T16:26:40ZMucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity10.1038/s41467-020-17307-02041-1723https://doaj.org/article/4d64013defa34421b522dd3241d24d0d2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17307-0https://doaj.org/toc/2041-1723Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.Amine ToubalBadr KiafLucie BeaudoinLucie CagninacciMoez RhimiBlandine FruchetJennifer da SilvaAlexandra J. CorbettYannick SimoniOlivier LantzJamie RossjohnJames McCluskeyPhilippe LesnikEmmanuelle MaguinAgnès LehuenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amine Toubal Badr Kiaf Lucie Beaudoin Lucie Cagninacci Moez Rhimi Blandine Fruchet Jennifer da Silva Alexandra J. Corbett Yannick Simoni Olivier Lantz Jamie Rossjohn James McCluskey Philippe Lesnik Emmanuelle Maguin Agnès Lehuen Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
description	Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducing dysbiosis of the intestinal microbiota.
format	article
author	Amine Toubal Badr Kiaf Lucie Beaudoin Lucie Cagninacci Moez Rhimi Blandine Fruchet Jennifer da Silva Alexandra J. Corbett Yannick Simoni Olivier Lantz Jamie Rossjohn James McCluskey Philippe Lesnik Emmanuelle Maguin Agnès Lehuen
author_facet	Amine Toubal Badr Kiaf Lucie Beaudoin Lucie Cagninacci Moez Rhimi Blandine Fruchet Jennifer da Silva Alexandra J. Corbett Yannick Simoni Olivier Lantz Jamie Rossjohn James McCluskey Philippe Lesnik Emmanuelle Maguin Agnès Lehuen
author_sort	Amine Toubal
title	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
title_short	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
title_full	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
title_fullStr	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
title_full_unstemmed	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
title_sort	mucosal-associated invariant t cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4d64013defa34421b522dd3241d24d0d
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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

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