Two TPX2-dependent switches control the activity of Aurora A.

Aurora A is an important oncogenic kinase for mitotic spindle assembly and a potentially attractive target for human cancers. Its activation could be regulated by ATP cycle and its activator TPX2. To understand the activation mechanism of Aurora A, a series of 20 ns molecular dynamics (MD) simulatio...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Xue Xu, Xia Wang, Zhengtao Xiao, Yan Li, Yonghua Wang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
R
Q
Acceso en línea:https://doaj.org/article/4d7475ab4421490787f7fdfea96a68ab
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!