Caspase-3/NLRP3 signaling in the mesenchymal stromal niche regulates myeloid-biased hematopoiesis

Caspase-3/NLRP3 signaling in the mesenchymal stromal niche regulates myeloid-biased hematopoiesis

Abstract Background The fate of hematopoietic stem cells (HSCs) is determined by a complex regulatory network that includes both intrinsic and extrinsic signals. In the past decades, many intrinsic key molecules of HSCs have been shown to control hematopoiesis homeostasis. Non-hematopoietic niche ce...

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Bibliographic Details
Main Authors: Jing Zhang, Yaozhen Chen, Dandan Yin, Fan Feng, Qunxing An, Zhixin Liu, Ning An, Jinmei Xu, Jing Yi, Shunli Gu, Wen Yin, Yazhou Wang, Xingbin Hu
Format: article
Language:EN
Published: BMC 2021
Subjects:
Mesenchymal stromal cells
Hematopoiesis
Myeloid development
Caspase-3
NLRP3 inflammasome
Medicine (General)
R5-920
Biochemistry
QD415-436
Online Access:https://doaj.org/article/4d9f95f8e15e4883a2b1d6ed28b6df9b
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https://doaj.org/article/4d9f95f8e15e4883a2b1d6ed28b6df9b

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