Translational roles of the C75 2′OH in an in vitro tRNA transcript at the ribosomal A, P and E sites

Abstract Aminoacyl-tRNAs containing a deoxy substitution in the penultimate nucleotide (C75 2′OH → 2′H) have been widely used in translation for incorporation of unnatural amino acids (AAs). However, this supposedly innocuous modification surprisingly increased peptidyl-tRNAAla ugc drop off in bioch...

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Autores principales: Jinfan Wang, Anthony C. Forster
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4dc37467c9fb4614b130d381bb418576
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