Translational roles of the C75 2′OH in an in vitro tRNA transcript at the ribosomal A, P and E sites
Abstract Aminoacyl-tRNAs containing a deoxy substitution in the penultimate nucleotide (C75 2′OH → 2′H) have been widely used in translation for incorporation of unnatural amino acids (AAs). However, this supposedly innocuous modification surprisingly increased peptidyl-tRNAAla ugc drop off in bioch...
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Formato: | article |
Lenguaje: | EN |
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Nature Portfolio
2017
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Acceso en línea: | https://doaj.org/article/4dc37467c9fb4614b130d381bb418576 |
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