Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits Ehretia tinifolia and Sideroxylon lanuginosum

Ehretia tinifolia Linnaeus (Boraginacea) and Sideroxylon lanuginosum Michaux (Sapotaceae) are wild fruits consumed in North America and are appreciated for their pleasant flavor and sweet taste. However, details regarding their composition and biological propert...

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Autores principales:	Imelda N. Monroy-García, Irma Edith Carranza-Torres, Pilar Carranza-Rosales, María Oyón-Ardoiz, Ignacio García-Estévez, Jesús Fernando Ayala-Zavala, Javier Morán-Martínez, Ezequiel Viveros-Valdez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	wild fruits antioxidant phenolic compounds HPLC-DAD-MS/MS Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/4dc67242b03b441584b84592670ab51c
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spelling	oai:doaj.org-article:4dc67242b03b441584b84592670ab51c2021-11-25T17:34:27ZPhenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>10.3390/foods101127102304-8158https://doaj.org/article/4dc67242b03b441584b84592670ab51c2021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2710https://doaj.org/toc/2304-8158<i>Ehretia tinifolia</i> Linnaeus (Boraginacea) and <i>Sideroxylon lanuginosum</i> Michaux (Sapotaceae) are wild fruits consumed in North America and are appreciated for their pleasant flavor and sweet taste. However, details regarding their composition and biological properties in the available literature are scarce. This study reports the phenolic composition, antioxidant, antiproliferative activities, and digestive enzymatic inhibition of amberlite-retained methanolic extracts from both fruits. Results revealed that these wild fruit extracts are rich in antioxidants. <i>S. lanuginosum</i> had lower phenolic but higher flavonoid contents (21.4 ± 1.5 mg GAE/100 g FW and 6.42 ± 0.9 mg CE/100 g FW) than <i>E. tinifolia</i> (64.7 ± 2.6 mg GAE/100 g FW and 5.1 ± 0.4 mg CE/100 g FW). HPLC-DAD-MS/MS analysis showed rosmarinic acid as a major polyphenol in <i>E. tinifolia</i> and quercetin glucoside in <i>S. lanuginosum</i>. Polyphenols content in <i>E. tinifolia</i> was related to a significant free radical scavenging ability: DPPH (EC<sub>50</sub> = 0.32 ± 0.03 mg/mL), TEAC (4134 ± 9.7 μM TE/g dry extract), and hemolysis inhibition (IC<sub>50</sub> = 58.55 ± 2.4 μg/mL). Both extracts were capable of inhibiting <i>α</i>-glucosidase, partially inhibiting <i>α</i>-amylase, and showed no inhibition against lipase, while showing antiproliferative activity against HeLa, HT-29 and MCF-7 cancer cell lines. Our study revealed that these wild fruit extracts are rich in health-beneficial phytochemicals and hold significant potential for elaborating functional foods.Imelda N. Monroy-GarcíaIrma Edith Carranza-TorresPilar Carranza-RosalesMaría Oyón-ArdoizIgnacio García-EstévezJesús Fernando Ayala-ZavalaJavier Morán-MartínezEzequiel Viveros-ValdezMDPI AGarticlewild fruitsantioxidantphenolic compoundsHPLC-DAD-MS/MSChemical technologyTP1-1185ENFoods, Vol 10, Iss 2710, p 2710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	wild fruits antioxidant phenolic compounds HPLC-DAD-MS/MS Chemical technology TP1-1185
spellingShingle	wild fruits antioxidant phenolic compounds HPLC-DAD-MS/MS Chemical technology TP1-1185 Imelda N. Monroy-García Irma Edith Carranza-Torres Pilar Carranza-Rosales María Oyón-Ardoiz Ignacio García-Estévez Jesús Fernando Ayala-Zavala Javier Morán-Martínez Ezequiel Viveros-Valdez Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>
description	<i>Ehretia tinifolia</i> Linnaeus (Boraginacea) and <i>Sideroxylon lanuginosum</i> Michaux (Sapotaceae) are wild fruits consumed in North America and are appreciated for their pleasant flavor and sweet taste. However, details regarding their composition and biological properties in the available literature are scarce. This study reports the phenolic composition, antioxidant, antiproliferative activities, and digestive enzymatic inhibition of amberlite-retained methanolic extracts from both fruits. Results revealed that these wild fruit extracts are rich in antioxidants. <i>S. lanuginosum</i> had lower phenolic but higher flavonoid contents (21.4 ± 1.5 mg GAE/100 g FW and 6.42 ± 0.9 mg CE/100 g FW) than <i>E. tinifolia</i> (64.7 ± 2.6 mg GAE/100 g FW and 5.1 ± 0.4 mg CE/100 g FW). HPLC-DAD-MS/MS analysis showed rosmarinic acid as a major polyphenol in <i>E. tinifolia</i> and quercetin glucoside in <i>S. lanuginosum</i>. Polyphenols content in <i>E. tinifolia</i> was related to a significant free radical scavenging ability: DPPH (EC<sub>50</sub> = 0.32 ± 0.03 mg/mL), TEAC (4134 ± 9.7 μM TE/g dry extract), and hemolysis inhibition (IC<sub>50</sub> = 58.55 ± 2.4 μg/mL). Both extracts were capable of inhibiting <i>α</i>-glucosidase, partially inhibiting <i>α</i>-amylase, and showed no inhibition against lipase, while showing antiproliferative activity against HeLa, HT-29 and MCF-7 cancer cell lines. Our study revealed that these wild fruit extracts are rich in health-beneficial phytochemicals and hold significant potential for elaborating functional foods.
format	article
author	Imelda N. Monroy-García Irma Edith Carranza-Torres Pilar Carranza-Rosales María Oyón-Ardoiz Ignacio García-Estévez Jesús Fernando Ayala-Zavala Javier Morán-Martínez Ezequiel Viveros-Valdez
author_facet	Imelda N. Monroy-García Irma Edith Carranza-Torres Pilar Carranza-Rosales María Oyón-Ardoiz Ignacio García-Estévez Jesús Fernando Ayala-Zavala Javier Morán-Martínez Ezequiel Viveros-Valdez
author_sort	Imelda N. Monroy-García
title	Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>
title_short	Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>
title_full	Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>
title_fullStr	Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>
title_full_unstemmed	Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>
title_sort	phenolic profiles and biological activities of extracts from edible wild fruits <i>ehretia tinifolia</i> and <i>sideroxylon lanuginosum</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4dc67242b03b441584b84592670ab51c
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Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits <i>Ehretia tinifolia</i> and <i>Sideroxylon lanuginosum</i>

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