Essential Role of STAT3 Signaling in Hair Follicle Homeostasis
Dominant-negative mutations associated with signal transducer and activator of transcription 3 (STAT3) signaling, which controls epithelial proliferation in various tissues, lead to atopic dermatitis in hyper IgE syndrome. This dermatitis is thought to be attributed to defects in STAT3 signaling in...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:4dcb772a5cd84371b7a0171122d63e7a2021-11-11T07:56:03ZEssential Role of STAT3 Signaling in Hair Follicle Homeostasis1664-322410.3389/fimmu.2021.663177https://doaj.org/article/4dcb772a5cd84371b7a0171122d63e7a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.663177/fullhttps://doaj.org/toc/1664-3224Dominant-negative mutations associated with signal transducer and activator of transcription 3 (STAT3) signaling, which controls epithelial proliferation in various tissues, lead to atopic dermatitis in hyper IgE syndrome. This dermatitis is thought to be attributed to defects in STAT3 signaling in type 17 helper T cell specification. However, the role of STAT3 signaling in skin epithelial cells remains unclear. We found that STAT3 signaling in keratinocytes is required to maintain skin homeostasis by negatively controlling the expression of hair follicle-specific keratin genes. These expression patterns correlated with the onset of dermatitis, which was observed in specific pathogen-free conditions but not in germ-free conditions, suggesting the involvement of Toll-like receptor-mediated inflammatory responses. Thus, our study suggests that STAT3-dependent gene expression in keratinocytes plays a critical role in maintaining the homeostasis of skin, which is constantly exposed to microorganisms.Kosuke MiyauchiSewon KiMasao UkaiMasao UkaiYoshie SuzukiKentaro InoueKentaro InoueWataru SudaWataru SudaTakeshi MatsuiYoshihiro ItoKenya HondaKenya HondaHaruhiko KosekiHaruhiko KosekiOsamu OharaOsamu OharaReiko J. TanakaMariko Okada-HatakeyamaMariko Okada-HatakeyamaMariko Okada-HatakeyamaMasato KuboMasato KuboFrontiers Media S.A.articleSTAT3 (signal transducer and activator of transcription 3)skinatopic dermatitisbacteriahair follicle (HF)Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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STAT3 (signal transducer and activator of transcription 3) skin atopic dermatitis bacteria hair follicle (HF) Immunologic diseases. Allergy RC581-607 |
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STAT3 (signal transducer and activator of transcription 3) skin atopic dermatitis bacteria hair follicle (HF) Immunologic diseases. Allergy RC581-607 Kosuke Miyauchi Sewon Ki Masao Ukai Masao Ukai Yoshie Suzuki Kentaro Inoue Kentaro Inoue Wataru Suda Wataru Suda Takeshi Matsui Yoshihiro Ito Kenya Honda Kenya Honda Haruhiko Koseki Haruhiko Koseki Osamu Ohara Osamu Ohara Reiko J. Tanaka Mariko Okada-Hatakeyama Mariko Okada-Hatakeyama Mariko Okada-Hatakeyama Masato Kubo Masato Kubo Essential Role of STAT3 Signaling in Hair Follicle Homeostasis |
| description |
Dominant-negative mutations associated with signal transducer and activator of transcription 3 (STAT3) signaling, which controls epithelial proliferation in various tissues, lead to atopic dermatitis in hyper IgE syndrome. This dermatitis is thought to be attributed to defects in STAT3 signaling in type 17 helper T cell specification. However, the role of STAT3 signaling in skin epithelial cells remains unclear. We found that STAT3 signaling in keratinocytes is required to maintain skin homeostasis by negatively controlling the expression of hair follicle-specific keratin genes. These expression patterns correlated with the onset of dermatitis, which was observed in specific pathogen-free conditions but not in germ-free conditions, suggesting the involvement of Toll-like receptor-mediated inflammatory responses. Thus, our study suggests that STAT3-dependent gene expression in keratinocytes plays a critical role in maintaining the homeostasis of skin, which is constantly exposed to microorganisms. |
| format |
article |
| author |
Kosuke Miyauchi Sewon Ki Masao Ukai Masao Ukai Yoshie Suzuki Kentaro Inoue Kentaro Inoue Wataru Suda Wataru Suda Takeshi Matsui Yoshihiro Ito Kenya Honda Kenya Honda Haruhiko Koseki Haruhiko Koseki Osamu Ohara Osamu Ohara Reiko J. Tanaka Mariko Okada-Hatakeyama Mariko Okada-Hatakeyama Mariko Okada-Hatakeyama Masato Kubo Masato Kubo |
| author_facet |
Kosuke Miyauchi Sewon Ki Masao Ukai Masao Ukai Yoshie Suzuki Kentaro Inoue Kentaro Inoue Wataru Suda Wataru Suda Takeshi Matsui Yoshihiro Ito Kenya Honda Kenya Honda Haruhiko Koseki Haruhiko Koseki Osamu Ohara Osamu Ohara Reiko J. Tanaka Mariko Okada-Hatakeyama Mariko Okada-Hatakeyama Mariko Okada-Hatakeyama Masato Kubo Masato Kubo |
| author_sort |
Kosuke Miyauchi |
| title |
Essential Role of STAT3 Signaling in Hair Follicle Homeostasis |
| title_short |
Essential Role of STAT3 Signaling in Hair Follicle Homeostasis |
| title_full |
Essential Role of STAT3 Signaling in Hair Follicle Homeostasis |
| title_fullStr |
Essential Role of STAT3 Signaling in Hair Follicle Homeostasis |
| title_full_unstemmed |
Essential Role of STAT3 Signaling in Hair Follicle Homeostasis |
| title_sort |
essential role of stat3 signaling in hair follicle homeostasis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/4dcb772a5cd84371b7a0171122d63e7a |
| work_keys_str_mv |
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