A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

Drosophila RNAi libraries are commonly used to perform large-scale functional genetics screens in vivo. Here the authors find that a subset of lines from the VDRC KK RNAi line cause false-positive enhancement of the Hippo pathway, and provide a strain that can test whether a genetic screen of intere...

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Autores principales:	Joseph H.A. Vissers, Samuel A. Manning, Aishwarya Kulkarni, Kieran F. Harvey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4def238a40cd4bc882d272cda03accde
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spelling	oai:doaj.org-article:4def238a40cd4bc882d272cda03accde2021-12-02T14:38:54ZA Drosophila RNAi library modulates Hippo pathway-dependent tissue growth10.1038/ncomms103682041-1723https://doaj.org/article/4def238a40cd4bc882d272cda03accde2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10368https://doaj.org/toc/2041-1723Drosophila RNAi libraries are commonly used to perform large-scale functional genetics screens in vivo. Here the authors find that a subset of lines from the VDRC KK RNAi line cause false-positive enhancement of the Hippo pathway, and provide a strain that can test whether a genetic screen of interest will be affected by this technical artefact.Joseph H.A. VissersSamuel A. ManningAishwarya KulkarniKieran F. HarveyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joseph H.A. Vissers Samuel A. Manning Aishwarya Kulkarni Kieran F. Harvey A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
description	Drosophila RNAi libraries are commonly used to perform large-scale functional genetics screens in vivo. Here the authors find that a subset of lines from the VDRC KK RNAi line cause false-positive enhancement of the Hippo pathway, and provide a strain that can test whether a genetic screen of interest will be affected by this technical artefact.
format	article
author	Joseph H.A. Vissers Samuel A. Manning Aishwarya Kulkarni Kieran F. Harvey
author_facet	Joseph H.A. Vissers Samuel A. Manning Aishwarya Kulkarni Kieran F. Harvey
author_sort	Joseph H.A. Vissers
title	A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
title_short	A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
title_full	A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
title_fullStr	A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
title_full_unstemmed	A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
title_sort	drosophila rnai library modulates hippo pathway-dependent tissue growth
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4def238a40cd4bc882d272cda03accde
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A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

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