A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11

Abstract Chronic otitis media with effusion (COME) is the most common cause of hearing loss in children, and known to have high heritability. Mutant mouse models have identified Fbxo11, Evi1, Tgif1, and Nisch as potential risk loci. We recruited children aged 10 and under undergoing surgical treatme...

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Autores principales: Mahmood F. Bhutta, Jane Lambie, Lindsey Hobson, Anuj Goel, Lena Hafrén, Elisabet Einarsdottir, Petri S. Mattila, Martin Farrall, Steve Brown, Martin J. Burton
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/4e3ad4f89c544c7ca34f1dfdf0d95724
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