A mouse-to-man candidate gene study identifies association of chronic otitis media with the loci TGIF1 and FBXO11
Abstract Chronic otitis media with effusion (COME) is the most common cause of hearing loss in children, and known to have high heritability. Mutant mouse models have identified Fbxo11, Evi1, Tgif1, and Nisch as potential risk loci. We recruited children aged 10 and under undergoing surgical treatme...
Enregistré dans:
Auteurs principaux: | Mahmood F. Bhutta, Jane Lambie, Lindsey Hobson, Anuj Goel, Lena Hafrén, Elisabet Einarsdottir, Petri S. Mattila, Martin Farrall, Steve Brown, Martin J. Burton |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2017
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/4e3ad4f89c544c7ca34f1dfdf0d95724 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
FBXO22 degrades nuclear PTEN to promote tumorigenesis
par: Meng-Kai Ge, et autres
Publié: (2020) -
Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.
par: Kenichiro Taniguchi, et autres
Publié: (2012) -
Premature senescence and increased TGFβ signaling in the absence of Tgif1.
par: Brad J Zerlanko, et autres
Publié: (2012) -
Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease
par: Christopher Grace, et autres
Publié: (2018) -
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
par: Nuria Cerdá-Esteban, et autres
Publié: (2017)