Rational design of complex phenotype via network models.
We demonstrate a modeling and computational framework that allows for rapid screening of thousands of potential network designs for particular dynamic behavior. To illustrate this capability we consider the problem of hysteresis, a prerequisite for construction of robust bistable switches and hence...
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Auteurs principaux: | Marcio Gameiro, Tomáš Gedeon, Shane Kepley, Konstantin Mischaikow |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2021
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Accès en ligne: | https://doaj.org/article/4e3fa112aaf9476398ffc49fdda9e05f |
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