Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor potential vanilloid 4 (TRPV4) channels lower pulmonary artery (PA) con...

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Bibliographic Details
Main Authors: Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2021
Subjects:
TRP channel
Pannexin 1
purinergic signaling
Caveolin 1
pulmonary vasculature
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/4e52c48d21c241c0a4496dbc4db01f8d
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https://doaj.org/article/4e52c48d21c241c0a4496dbc4db01f8d

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