Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part...

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Autores principales: Naveed Ishaque, Mohammed L. Abba, Christine Hauser, Nitin Patil, Nagarajan Paramasivam, Daniel Huebschmann, Jörg Hendrik Leupold, Gnana Prakash Balasubramanian, Kortine Kleinheinz, Umut H. Toprak, Barbara Hutter, Axel Benner, Anna Shavinskaya, Chan Zhou, Zuguang Gu, Jules Kerssemakers, Alexander Marx, Marcin Moniuszko, Miroslaw Kozlowski, Joanna Reszec, Jacek Niklinski, Jürgen Eils, Matthias Schlesner, Roland Eils, Benedikt Brors, Heike Allgayer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/4e68117793d04d9682b7c9652d4393b8
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spelling oai:doaj.org-article:4e68117793d04d9682b7c9652d4393b82021-12-02T16:49:52ZWhole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer10.1038/s41467-018-07041-z2041-1723https://doaj.org/article/4e68117793d04d9682b7c9652d4393b82018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07041-zhttps://doaj.org/toc/2041-1723The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part, are therapeutically actionable.Naveed IshaqueMohammed L. AbbaChristine HauserNitin PatilNagarajan ParamasivamDaniel HuebschmannJörg Hendrik LeupoldGnana Prakash BalasubramanianKortine KleinheinzUmut H. ToprakBarbara HutterAxel BennerAnna ShavinskayaChan ZhouZuguang GuJules KerssemakersAlexander MarxMarcin MoniuszkoMiroslaw KozlowskiJoanna ReszecJacek NiklinskiJürgen EilsMatthias SchlesnerRoland EilsBenedikt BrorsHeike AllgayerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Naveed Ishaque
Mohammed L. Abba
Christine Hauser
Nitin Patil
Nagarajan Paramasivam
Daniel Huebschmann
Jörg Hendrik Leupold
Gnana Prakash Balasubramanian
Kortine Kleinheinz
Umut H. Toprak
Barbara Hutter
Axel Benner
Anna Shavinskaya
Chan Zhou
Zuguang Gu
Jules Kerssemakers
Alexander Marx
Marcin Moniuszko
Miroslaw Kozlowski
Joanna Reszec
Jacek Niklinski
Jürgen Eils
Matthias Schlesner
Roland Eils
Benedikt Brors
Heike Allgayer
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
description The evolution and genetic nature of metastatic lesions is not completely characterized. Here the authors perform a comprehensive whole-genome study of colorectal metastases in comparison to matched primary tumors and define a multistage progression model and metastasis-specific changes that, in part, are therapeutically actionable.
format article
author Naveed Ishaque
Mohammed L. Abba
Christine Hauser
Nitin Patil
Nagarajan Paramasivam
Daniel Huebschmann
Jörg Hendrik Leupold
Gnana Prakash Balasubramanian
Kortine Kleinheinz
Umut H. Toprak
Barbara Hutter
Axel Benner
Anna Shavinskaya
Chan Zhou
Zuguang Gu
Jules Kerssemakers
Alexander Marx
Marcin Moniuszko
Miroslaw Kozlowski
Joanna Reszec
Jacek Niklinski
Jürgen Eils
Matthias Schlesner
Roland Eils
Benedikt Brors
Heike Allgayer
author_facet Naveed Ishaque
Mohammed L. Abba
Christine Hauser
Nitin Patil
Nagarajan Paramasivam
Daniel Huebschmann
Jörg Hendrik Leupold
Gnana Prakash Balasubramanian
Kortine Kleinheinz
Umut H. Toprak
Barbara Hutter
Axel Benner
Anna Shavinskaya
Chan Zhou
Zuguang Gu
Jules Kerssemakers
Alexander Marx
Marcin Moniuszko
Miroslaw Kozlowski
Joanna Reszec
Jacek Niklinski
Jürgen Eils
Matthias Schlesner
Roland Eils
Benedikt Brors
Heike Allgayer
author_sort Naveed Ishaque
title Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
title_short Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
title_full Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
title_fullStr Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
title_full_unstemmed Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
title_sort whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/4e68117793d04d9682b7c9652d4393b8
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