High Expression of <i>PPM1D</i> Induces Tumors Phenotypically Similar to <i>TP53</i> Loss-of-Function Mutations in Mice

High Expression of <i>PPM1D</i> Induces Tumors Phenotypically Similar to <i>TP53</i> Loss-of-Function Mutations in Mice

<i>PPM1D</i> is a negative regulator of p53 and genomic aberrations resulting in increased activity of <i>PPM1D</i> have been observed in cancers of different origins, indicating that <i>PPM1D</i> has oncogenic properties. We established a transgenic mouse model o...

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Autores principales: Jelena Milosevic, Susanne Fransson, Miklos Gulyas, Thale K. Olsen, Gabriel Gallo-Oller, Diana Treis, Lotta H. M. Elfman, Margareta Wilhelm, Tommy Martinsson, Ninib Baryawno, Per Kogner, John Inge Johnsen
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>PPM1D</i>
p53
genetically engineered mouse model
adenocarcinoma
lymphoma
neuroblastoma
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/4e7642724943438284674a8797264157
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https://doaj.org/article/4e7642724943438284674a8797264157

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