Hepatocyte-specific TM6SF2 knockout aggravates hepatic steatosis in mice with nonalcoholic fatty liver disease

ObjectiveTo establish a mouse model of hepatocyte-specific TM6SF2 knockout, and to investigate the role of TM6SF2 in the development of nonalcoholic fatty liver disease (NAFLD). MethodsThe CRISPR/Cas9 technique and the Cre/LoxP strategy were used to establish a stable mouse model of hepatocyte-speci...

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Autor principal: ZHANG Jie
Formato: article
Lenguaje:ZH
Publicado: Editorial Department of Journal of Clinical Hepatology 2021
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Acceso en línea:https://doaj.org/article/4e7a05c4f9d44d5daeec0bea31f797ff
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